Commitment to Humane Care and Well-Being of Research Animal Models
Animals are essential to our understanding of disease progression and biological mechanisms as well as drug safety and efficacy. Before any drug or therapy is brought to market, there are regulations requiring testing in animal models to identify any health or safety risks as well as effectiveness. When animal models are required, the research is highly regulated to ensure responsible, ethical, and humane treatment. You can learn more about our commitment to the humane care and well-being of all animals that we work by reading our Animal Welfare and Humane Treatment of Animals Policy.
Facts about Animals in Research
- Human and animal anatomy is comparable, with our organ systems performing in very similar ways
- Humans share approximately 99% of our DNA with mice, making them particularly effective models
- Approximately 95% of all animals involved in research are mice, rats, and fish
- Veterinary research also benefits from animals in research, providing medicines for companion and farm animals
3Rs
The 3Rs principle (Replacement, Reduction, and Refinement) was developed over 50 years ago to provide a framework for performing animal research. Charles River has a long and proud history of investing in and embracing the components of the 3Rs principle.
We are committed to leading the industry in adopting the 3Rs, identifying technologies to reduce the use of animals, and supporting efforts by global regulatory bodies to advance solutions that reduce the use of animals while protecting patient safety.
Humane Care Imperative
Our Humane Care Imperative includes establishing industry best practices and providing education and training to increase awareness of the importance of humane care, fostering animal welfare worldwide. All Charles River employees - whether they work with animals or not - are committed to the highest level of animal welfare. We comply with standards of practice and accepted guidance for the care and use of laboratory animals. Moreover, we participate in voluntary oversight programs, such as AAALAC International that promotes the responsible treatment of animals in science through a voluntary accreditation program, to assess our compliance through in-depth evaluations of our facilities and practices.
Focus Areas
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Research Animal Behavioral Management
Behavioral Management Programs (BMP) are intended to ensure optimal environments, husbandry, handling, and management of all animals in our care. These programs focus on a holistic view of animal care for the specific species and individual animal.
- Dynamic environmental enrichment programs that consider species-specific welfare requirements.
- Proactive management programs that provide physiological and behavioral well-being for our animals.
- Ongoing commitment to develop best practices in behavioral management and environmental enrichment strategies.
We offer a complimentary guide to the behavior and enrichment of laboratory rodents covering species-typical behavior as well as abnormal/malfunctional behavior and stereotypes observed in mice, rats, hamsters, and gerbils, this is an excellent resource for those looking to implement or enhance an existing behavioral husbandry and enrichment program. -
Humane Care
- Active participation at numerous national and international scientific meetings to ensure we both obtain and impart knowledge about best practices.
- Establishment of an Animal Oversight Body or Institutional Animal Care and Use Committee responsible for each site. Representatives of these committees across all sites meet together on a regular basis to establish guidelines and identify and harmonize best practices.
- Regular site visits by the senior members of the Global Animal Welfare and Training group to identify areas of excellence and facilitate sharing of this information with others.
- Establishment of a network of Animal Welfare Specialists for all business units worldwide. These individuals are appointed by the CEO and work with Global Animal Welfare and Training on a regular basis.
- Commitment to promoting compassion, resiliency, and the well-being of personnel working with animals. Charles River’s Compassion Science Program helps personnel to recognize signs of compassion stress in themselves and others, provides support to employees, helps to increase consistency in work quality and excellent animal care, and increases employee satisfaction.
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Orientation and Training
- When new employees join Charles River, they are welcomed to the company with a Cultural Orientation Program. A central message to new employees is our commitment to animal welfare. All employees are asked to embrace humane care as a critical element of how Charles River supports accelerating drug development.
- Employees learn about the 3Rs of animal welfare: Replacement, Reduction, Refinement, and incorporate Charles River’s Culture of Care into their daily work. They also learn about their obligation to report any animal welfare concerns and then sign a Humane Care Commitment after completing their orientation.
- Formal training in animal welfare recurs annually, at minimum. Employees with direct contact with the animals re-sign the Humane Care Commitment statement after each annual update.
- There are internal information channels such as our quarterly newsletters, intranet site, and annual All-Hands meetings that keep employees current on animal welfare, the 3Rs at Charles River, and the latest news regarding the Humane Care Imperative.
- A network of trainers helps to ensure that our sites are working together to raise the bar for the humane care and welfare of our animals. These groups meet regularly for advanced training, networking, discussion, case studies, and other activities related to advancing humane care. The network reinforces the objectives of the Humane Care Imperative and gives our employees a local outlet for ideas, questions, or concerns.
- We believe strongly in providing continuing education opportunities to our network of trainers through retreats and workshops. These bring together employees from sites around the globe and reinforce our commitment to their development and to promoting best practices within the company and the industry.
The Humane Care Imperative is directed by our Global Animal Welfare and Training group, which consists of professionals committed to animal welfare with expertise in laboratory animal medicine and science, training, and ethics. Charles River has a staff of over 150 veterinarians and over 10,000 animal care professionals dedicated to the care and well-being of animals at its facilities globally.